http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=31397
http://www.polymvasurvivors.com/index.html
* Breast cancer patients with low levels of vitamin D followed over eleven years had a 70% greater chance of dying and twice the rate of developing metastasis than patients with high levels of vitamin D.
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Frequency of Vitamin D (Vit D) Deficiency at Breast Cancer (BC) Diagnosis and Association with Risk of Distant Recurrence and Death in a Prospective Cohort Study of T1-3, N0-1, M0 BC.
Abstract:
Background:
Vit D supplementation is common in BC. Given reports that Vit D modulates aromatase activity, we examined the relationship between Vit D and estrogen levels in PM BC.
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Methods: 125 PM women within 2 years of diagnosis of T1-3, N0-3, M0 BC were recruited in Toronto and Los Angeles between Mar 2009 and Jan 2010. Data included: anthropometrics (measured); medications and Vit D supplementation (structured interview); and tumor/treatment variables (clinical records).
Serum was analyzed for 25(OH)D by radioimmunoassay (RIA) and estradiol (E2) and estrone (E1) by extraction-column chromatography-RIA. Statistical analyses used t-tests, Pearson correlation (r) and regression models after suitable transformation of variables.
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Results: Hormone therapies included AIs (n=56), tamoxifen (n=30) and none (n=39). The tamoxifen and no hormone groups did not differ for important variables, and were combined (non-AI, n=69).
Mean age was 62 years, BMI 27 kg/m2, Vit D supplementation 1244 IU/day, 25(OH)D 98 nmol/L; these attributes were similar in AI users and non-users. Mean E2 and E1 levels (pmol/L) were significantly lower in AI users (19.9 and 26.2) than non-users (39.6 and 123.7), both p<0.0001.
The relationship between 25(OH)D and E2 differed qualitatively in AI users vs non-users (interaction p = 0.002): in AI users, 25(OH)D was positively correlated with E2 (r = + 0.31, p=0.02); in non-AI users this correlation was negative (r = - 0.26, p=0.03). 25(OH)D was not associated with E1 in either group.
BMI was not associated with either E1 or E2 in AI-users (r = +0.09, p=0.52; r = - 0.03, p=0.84), but was univariably associated with E1 but not E2 in non-AI users (r = +0.44, p=0.0001, and r = +0.22, p=0.07). In multivariable analyses [age, BMI, 25(OH)D], 25(OH)D was positively associated with E2 in AI users (p=0.04) and negatively in non-AI users (p=0.05).
BMI was associated with E1 in non-AI users (p=0.002). Measurement of AI levels is underway.
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Conclusions:
In PM BC survivors, serum 25(OH)D was associated with higher E2 among AI users but not non-AI users. If replicated, this finding has implications for BC survivors receiving AIs. Funded by the Breast Cancer Research Foundation.
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http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=31397
http://www.polymvasurvivors.com/index.html
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